Halothane


234



General information:


Withdrawn ID: 234
Canonical SMILES:
Standard InChI:
Standard InChIKey:
ATC class(es): N01AB01
Molecular Formula: C2HBrClF3
Molweight: 197.382



Withdrawal information:


Withdrawn due to drug safety reasons:No
First approved: 1958
First withdrawn: 1980



Side-effects:

Total reported cases (submitted by medical professionals) with Halothane as primary suspect: 12


Reported final outcomes:
Intervention required to prevent permanent impairment/damage: 7
Life-Threatening condition: 4
Death: 3
Hospitalization (initial or prolonged): 2


Reported side-effects:

Side-effect Case number
HEPATITIS FULMINANT2
COMA2
CARDIAC ARREST1
GRAND MAL CONVULSION1
END-TIDAL CO2 INCREASED1
Encephalopathy1
DRUG TOXICITY1
DRUG HYPERSENSITIVITY1
DISORIENTATION1
DELAYED RECOVERY FROM ANAESTHESIA1
COAGULOPATHY1
CARDIAC OUTPUT DECREASED1
HEPATIC ENCEPHALOPATHY1
BODY TEMPERATURE INCREASED1
BLOOD POTASSIUM INCREASED1
ARTHRALGIA1
ARRHYTHMIA SUPRAVENTRICULAR1
APALLIC SYNDROME1
ANAESTHETIC COMPLICATION CARDIAC1
ALCOHOL WITHDRAWAL SYNDROME1
AIRWAY COMPLICATION OF ANAESTHESIA1
Accidental exposure to product1
ABDOMINAL PAIN1
MECHANICAL VENTILATION COMPLICATION1
VENTRICULAR EXTRASYSTOLES1
URINARY RETENTION POSTOPERATIVE1
TORSADE DE POINTES1
SPLENOMEGALY1
SPLEEN CONGESTION1
RESPIRATORY ACIDOSIS1
RENAL FAILURE ACUTE1
PULMONARY CONGESTION1
METABOLIC ACIDOSIS1
MENTAL STATUS CHANGES1
VENTRICULAR TACHYCARDIA1
LIVER TRANSPLANT1
LARYNGOSPASM1
JAUNDICE1
HYPERTHERMIA MALIGNANT1
HEPATOTOXICITY1
HEPATORENAL SYNDROME1
HEPATOCELLULAR DAMAGE1
HEPATIC NECROSIS1
HEPATIC FAILURE1





Toxicity information:

Toxicity class: 6
Toxicity type: N/A
LD50: 5680 mg/kg



External links:

ChEBML: CHEMBL931
DrugBank: DB01159